080076: Binding Protein for Detecting Phosphatidic Acid
Case ID:
TEC2008-0076
Web Published:
7/21/2014
Description:
Phosphatidic acid (PA) is an essential
component of living cells. PA-signaling processes are extremely important
biochemical pathways that are likely implicated in many diseases and in the
pathology of serious health conditions. Its detection and measurement can be
very important for basic science and biomedical research. Current methods for
detecting PA are difficult, expensive, and widely considered adequate at best.
This hampers important biomedical research related to basic cellular
biochemistry and pathologies.
Description
MSU’s invention relates to the
identification and cloning of a newly characterized PA-binding protein, TGD2,
and the uses of this protein as the basis of new methods to detect and measure
PA. These methodologies are based on the specific molecular interaction of the
protein with PA. The TGD2 protein is unique in that it interacts only with PA
and offers a level of specificity not achievable with other reagents.
Benefits
·
Direct and
simple:
New in-vitro assay procedures enabled by
this discovery replace the complex, indirect biochemical methods required by
traditional detection and measurement
methods.
·
Affordable:
Eliminates the need
for complex and expensive equipment that is unavailable to most
laboratories.
·
Unique
intracellular localization and assay platform:
Permits simple assay
development for high-content screening and research applications involving PA
biochemistry and signaling.
Applications
Phosphatidic acid detection can be used across an array of applications
and industries, including the following:
·
Life
science reagents for studying PA biochemistry and cellular signal transduction
pathways
in biomedical research
·
High-content
screening by individual drug discovery companies within the
biotechnology
and pharmaceutical industry with interest in
PA-biochemistry
·
Possible
target for herbicide development by Agro-biotech companies due to
TGD2’s
IP Protection Status
Patent
pending
Patent Information:
| App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Expire Date |
For Information, Contact:
Thomas Herlache
Assistant Director
Michigan State University - Test
517-355-2186
herlache@msu.edu
