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Genetic Targets and Gene Therapies for Treating Levodopa-induced Dyskinesias for Parkinsonisms

The Parkinson’s Disease Foundation estimates that there are 1.0 to 1.5 million people suffering from Parkinson’s disease (PD) in the United States alone. Those suffering from PD are afflicted with tremors in the limbs and face, rigidity and stiffness of the limbs and trunk, slowed movement, postural instability, and impaired balance. Presently,...
Published: 7/21/2014   |   Inventor(s): Jack Lipton, Kathy SteecE-Collier, Nicholas Kanaan, Timothy Collier, Fredric Manfredsson, Caryl Sortwell
Keywords(s):   Category(s): Medical, Pharmaceutical, Therapeutic

"U.S. v. Narciso, Perez & the Press"

Using interviews, archival video and photos, and FBI documents obtained via FOIA, U.S. v. Narciso, Perez & the Press is a half-hour documentary that reconstructs the trial of two Filipina nurses convicted of poisoning patients in the VA Hospital in Ann Arbor, MI in the 1970s. During a six-week period in the summer of 1975, 27 patients experienced...
Published: 7/21/2014   |   Inventor(s): Geraldine Zeldes
Keywords(s):   Category(s): Medical, Communication, Pharmaceutical

Layered Skin Suturing Pad - Intramuscular Injection Training Pad - Subcutaneous Injection Training Pad - Cystocentesis/Bladder Palpation Training Block - Bovine Tail Venipuncture Model

Veterinary training requires that a student master certain techniques that require fine motor control – a skill that can only be obtained through repeated practice. A major issue during veterinary training is simulating the tactile sensation of live patients – skin, muscle, fat, and bone all offer varying resistance to applied pressure,...
Published: 7/21/2014   |   Inventor(s): Beatrice Biddinger
Keywords(s):   Category(s): Medical, Animal/Veterinary, Devices, Veterinary

Field-operable nuclear magnetic resonance (NMR)-based biosensor with embedded temperature control

Innovators at Michigan State University developed a portable Nuclear Magnetic Resonance (NMR)-based biosensor that utilizes magnetic nanoparticles as a biomarker for label-free isolation and detection of target bio-materials from complex sample matrices. The NMR-based biosensor operates at 0.47 Tesla, utilizing an embedded magnet and electrically-active...
Published: 7/30/2014   |   Inventor(s): Evangelyn Alocilja, Yilun Luo
Keywords(s):   Category(s): Medical, Biotechnology, Nanotechnology, Devices, Test and Measurement

110032: Hydrogel Microparticles for Targeted Drug Delivery

Drug delivery is the process of administering a pharmaceutical compound to achieve a therapeutic effect. Drug delivery technologies can modify drug release profile, absorption, distribution, and elimination for the benefit of the patient. A current area of drug delivery research relates to targeted delivery models in which drugs are delivered only...
Published: 7/21/2014   |   Inventor(s): Jeffrey Sakamoto, Daniel Lynam, Robert Sanders, Christina Chan, Bridget Bednark
Keywords(s): Drug Delivery, Hydrogel, Implant, Microneedles Category(s): Medical, Pharmaceutical

100099: Compressive Spike Sorting for Neural Implants

Many companies sell neurophysiology data acquisition systems that are bulky, wired, and very expensive, requiring large computational power via PCs to sort neural spikes. In addition, the spike-sorting task is a fundamental step in the design of clinically viable brain machine interfaces for restoring normal sensory and motor function of disabled...
Published: 7/21/2014   |   Inventor(s): Karim Oweiss, Mehdi Aghagolzadeh
Keywords(s): Algorithm, Electrodes, Neural Network, Waveform Analysis Category(s): Medical, Biotechnology

100041: Symptom Management Toolkit for Caregivers of Cancer Patients

Cancer patients have numerous symptoms, both from the cancer itself and from the side effects of its treatments. Since many cancer treatments are delivered as outpatient procedures or via oral medicines, cancer patients and their caregivers often are dealing with symptoms from treatment and/or disease progression at home. They have significant...
Published: 7/21/2014   |   Inventor(s): Barbara Given, Charles Given, Cindy Majeske, Emily Miezio
Keywords(s): Cancer, Symptom Management Category(s): Medical

100020: Quantitative Diagnostic Test for Malaria

Malaria, a devastating disease caused by parasites, results in 350–500 million infections and approximately 1 million deaths per year, primarily in Africa. The disease affects mainly children under the age of 5 years who have not yet established immunity against the parasite. With symptoms resembling influenza or cold, mild malaria infection can...
Published: 7/21/2014   |   Inventor(s): Karl Seydel, Terrie Taylor
Keywords(s): Cerebral Malaria, HRP2, Malaria Category(s): Medical, Biotechnology

090024: X-Plant Spinal Fixator

Lumbar fusion surgery is used for a variety of lumbar spine problems. Initially, most lumbar spine problems are treated conservatively. If symptoms persist, some individuals may be candidates for lumbar spine fusion surgery. The goal of such surgery is to relieve pain, numbness, and weakness, to restore nerve function, and to stop or prevent abnormal...
Published: 7/21/2014   |   Inventor(s): Lawrence Mysliwiec
Keywords(s): Fixation, Lumbar, Orthopedic, Percutaneous, Spine, Surgery Category(s): Medical, Mechanical

090010: Single Nucleotide Polymorphism (SNP) Genotyping of E. Coli 0157:H7

E. coli O157:H7 is a major health problem causing infection in more than 70,000 patients a year in the United States. These infections may be both in large outbreaks as well as isolated sporadic infections in small numbers of individuals. The Center for Disease Control (CDC) typically uses Pulse Field Gel Electrophoresis (PFGE) for identifying...
Published: 7/21/2014   |   Inventor(s): Thomas Whittam, Shannon Manning, David Alland, Alifiya Motiwala
Keywords(s): E. Coli, Food Safety, Rapid Test, SNP Genotyping Category(s): Medical, Biotechnology, Environment
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