Search Results - pharmaceutical

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Genetic Targets and Gene Therapies for Treating Levodopa-induced Dyskinesias for Parkinsonisms

The Parkinson’s Disease Foundation estimates that there are 1.0 to 1.5 million people suffering from Parkinson’s disease (PD) in the United States alone. Those suffering from PD are afflicted with tremors in the limbs and face, rigidity and stiffness of the limbs and trunk, slowed movement, postural instability, and impaired balance. Presently,...
Published: 7/21/2014   |   Inventor(s): Jack Lipton, Kathy SteecE-Collier, Nicholas Kanaan, Timothy Collier, Fredric Manfredsson, Caryl Sortwell
Keywords(s):   Category(s): Medical, Pharmaceutical, Therapeutic

"U.S. v. Narciso, Perez & the Press"

Using interviews, archival video and photos, and FBI documents obtained via FOIA, U.S. v. Narciso, Perez & the Press is a half-hour documentary that reconstructs the trial of two Filipina nurses convicted of poisoning patients in the VA Hospital in Ann Arbor, MI in the 1970s. During a six-week period in the summer of 1975, 27 patients experienced...
Published: 7/21/2014   |   Inventor(s): Geraldine Zeldes
Keywords(s):   Category(s): Medical, Communication, Pharmaceutical

110032: Hydrogel Microparticles for Targeted Drug Delivery

Drug delivery is the process of administering a pharmaceutical compound to achieve a therapeutic effect. Drug delivery technologies can modify drug release profile, absorption, distribution, and elimination for the benefit of the patient. A current area of drug delivery research relates to targeted delivery models in which drugs are delivered only...
Published: 7/21/2014   |   Inventor(s): Jeffrey Sakamoto, Daniel Lynam, Robert Sanders, Christina Chan, Bridget Bednark
Keywords(s): Drug Delivery, Hydrogel, Implant, Microneedles Category(s): Medical, Pharmaceutical

080066: A Potential E. coli Vaccine to Prevent Travelers’ Diarrhea

080066: Highly Immunogenic E. coli heat-stable enterotoxin (STa) vaccine Categories: MedicalAnimal/Veterinary Pharmaceutical Therapeutic BackgroundEnterotoxic E. coli strains (ETEC) produce heat stable enterotoxin (STa). ETEC strains are a common cause of diarrhea (travelers’ diarrhea in humans) and animals (scours). Each year, approximately...
Published: 7/21/2014   |   Inventor(s): A. Mahdi Saeed
Keywords(s): Enterotoxin, Vaccine Category(s): Medical, Animal/Veterinary, Pharmaceutical, Therapeutic

080062: Adaptation of Human (Pro)renin Receptor for Drug Screening

The recent discovery of (pro)renin receptor, PRR, may have significant implications for intracellular signaling. Moreover, animal studies of PRR have shown that its gene knockout results in lifelessness. Thus, an understanding of PRR could lead to one or more valuable therapies. PRR is also involved in the regulation of blood pressure at a “localized”...
Published: 7/21/2014   |   Inventor(s): R. Michael Garavito, Dexin Sui, Yi Zheng
Keywords(s): ACE Inhibitors, Anti-Hypertension, Anti-Hypertensive Therapy, Prorenin, PRR, Renin Category(s): Medical, Biotechnology, Pharmaceutical

050075: Inhibition of Cancer Cells Expressing Activated Ras Gene by Reducing the Expression of Sprouty with RNA Interference or Similar Technologies

According to the CDC, cancer is the second leading cause of death in the U. S., killing more than 553,000 Americans each year. Control of this disease is a national priority. There are many mechanisms by which normal cells can be transformed into cancer cells. One that is well known and associated with a large number of cancers is mutation of the...
Published: 7/21/2014   |   Inventor(s): Justin Mccormick, Piro Lito
Keywords(s): Cancer, Ras Oncology, SiRNA, Sprouty Protein Category(s): Medical, Biotechnology, Pharmaceutical

050074: PCR-Based Capsular Typing Method for Serotyping Group B Streptococci

Group B streptococci (GBS), although generally carried asymptotically, can cause invasive disease in newborns, pregnant women, and immunocompromised adults. This bacteria is the most common cause of neonatal and obstetric sepsis and an increasing cause of septicemia in the elderly and immunocompromised patients. It affects approximately 20,000 people/year,...
Published: 7/21/2014   |   Inventor(s): Herbert Davies, Thomas Whittam, Shannon Manning, David Lacher
Keywords(s): Capsular Typing, Group B Streptococci, PCR, Restriction Fragment Length Polymorphism Category(s): Medical, Biotechnology, Pharmaceutical

040108: Method for the Separation of Peptide or Protein Materials

The recent focus on proteomics research has resulted in an increased demand for sophisticated methods to identify and analyze post-translational processing of proteins for the purpose of analyzing cellular signaling networks and diagnosing diseases. The reversible process of phosphorylation/dephosphorylation is one modification that is critical...
Published: 7/21/2014   |   Inventor(s): Jetze Tepe, Thomas Pinnavaia
Keywords(s): Phosphorylated Proteins and Peptides, Proteomics Category(s): Biotechnology, Pharmaceutical, Test and Measurement

040020: Engineering Functional Groups into Electrospun Nanofibers for Cell Culture

Cell culturing is the process of growing cells in an artificial environment under controlled conditions in an effort to cause the cells to behave as they would in vivo. This is difficult to achieve because, in addition to the conditions such as temperature, pH, and gas concentrations, nutrients and energy requirements must be supplied in cell culture...
Published: 7/21/2014   |   Inventor(s): Melvin Schindler, Hoo Chung
Keywords(s): Cell Culture, Cell Culture Additives, Nanofibrillar Surfaces, Sythetic Extracellular Matrix Category(s): Biotechnology, Test and Measurement, Pharmaceutical

040006: Compositions and Methods for Immunotherapy of Cancer and Infectious Diseases

Background A principal goal in the development of immunotherapies is to achieve a safe and effective activation of the immune system. One of the early signals of T lymphocyte and Natural Killer cell activation is the induction in expression of the cell surface glycoprotein CD69. This protein is involved in lymphocyte proliferation and functions as a...
Published: 7/21/2014   |   Inventor(s): Charles Aylsworth, David Juckett, Igor Zlatkin, Tatiana Zlatkin, John Judge, John SiU-Cheong Ho
Keywords(s): Cancer, Immune Response, Pharmaceuticals Category(s): Medical, Pharmaceutical
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