MSU Technologies

030052: Preparation of Hymenialdisine Derivatives and potential Application to Treatment of Inflammatory Diseases, Alzheimer's, and Cancer

Description:

Cyclin-dependent kinases and NF-kB regulate a large number of genes and biochemical pathways. Deviations in their activity are associated with diseases, including those linked to immune, inflammatory, and anti-apoptotic responses. Many areas of drug discovery are focused on discovery of reagents that inhibit their activities.

Naturally occurring compounds that are identified through marine biology represent a broad spectrum of potentially useful compounds. The multi-ring indolazepine derivatives described here are closely related to hymenialdisine compounds that have been isolated from marine sponges and are known to be potent kinase and NF-kB inhibitors.

Description

This technology consists of indolazepines, which are hymenialdisine-related compounds that inhibit NF-kB and cyclin-dependent kinases. These compounds have the potential for anti-inflammatory activity and inhibition of cancer cells. This invention describes in vitro biological activity and methods for synthesis and production of these unique indolazepine compounds.

Benefits

More potent inhibition of cyclin-dependent kinase and NF-KB activity: Will potentially lead to an effective inhibitor which has improved efficacy over hymenialdisine and other inhibitory molecules.
Method for synthesis: Will provide the ability to produce pure, active material.

Applications

These compounds can potentially be used on their own, or in combination with complementary drugs or compounds in the treatment of a wide variety of medical conditions including inflammatory disorders such as arthritis, asthma, Alzheimer's, and cancers.